Plant Transcription Factor Database
Previous version: v3.0
Ocimum tenuiflorum
E2F/DP Family
Species TF ID Description
Ote100071000061E2F/DP family protein
Ote100075330131E2F/DP family protein
Ote100081250031E2F/DP family protein
Ote100081250051E2F/DP family protein
Ote100136550081E2F/DP family protein
Ote100136550091E2F/DP family protein
Ote100167300041E2F/DP family protein
Ote100191540021E2F/DP family protein
Ote100203620031E2F/DP family protein
Ote100225360121E2F/DP family protein
Ote100251890111E2F/DP family protein
Ote100261430121E2F/DP family protein
Ote100275380021E2F/DP family protein
Ote100275380041E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710